The Human Upgrade with Dave Asprey

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For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.

You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.

Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.

Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life. 

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  • Company address: 333 Influence St, Expressed City, CA 37373
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Recent Hosts, Guests & Topics

Here's a quick summary of the last 5 episodes on The Human Upgrade with Dave Asprey.

Hosts

Dave Asprey

Previous Guests

Ulrich Dempfle
Ulrich Dempfle is a German-trained engineer and co-founder of CAROL Bike, a company that specializes in creating innovative fitness solutions. With a background in engineering, Ulrich has dedicated his career to developing efficient training methods that challenge traditional cardio workouts. He is a proponent of Reduced Exertion High-Intensity Training (REHIT), which emphasizes short, intense bursts of exercise to achieve significant fitness gains in minimal time. His work focuses on dismantling outdated fitness myths and providing data-driven insights into effective training protocols.
Dr. Daniel Pompa
Dr. Daniel Pompa is a leading voice in cellular detox and root-cause healing. He has a background in health and wellness, focusing on the underlying causes of chronic illness. Dr. Pompa has experienced a personal health collapse, which has driven his passion for understanding cellular dysfunction, neurotoxicity, and hormone resistance. He is known for his work in exposing hidden stressors that affect energy and overall health, and he advocates for a holistic approach to healing that addresses the root causes rather than just symptoms.
Sbastien Page
Sbastien Page is the Chief Investment Officer (CIO) of one of the world's largest investment firms, managing over $500 billion in global assets. He is also the author of 'The Psychology of Leadership,' a book that explores the dynamics of leadership under pressure. With extensive experience in high-stakes environments, Page has developed a unique perspective on stress, viewing it not as a hindrance but as a tool for enhancing performance, clarity, and control. His insights draw from his experiences in the financial sector and his understanding of the psychological aspects of leadership.
Michael Tiffany
Michael Tiffany is the CEO of Fulcra.ai, a company focused on developing advanced technologies for data privacy and security. With a background in computer science and a passion for innovation, he has been at the forefront of integrating AI and blockchain to enhance personal data protection and ownership.
Vishakh
Vishakh is the founder of Monadic DNA, a company dedicated to revolutionizing the way genetic data is handled and monetized. He is an expert in genomic privacy and has a mission to empower individuals to profit from their genetic information while ensuring its security and confidentiality.
Dr. Steven Gundry
Dr. Steven Gundry is a renowned cardiothoracic surgeon and a pioneer in the field of nutrition and gut health. He is the author of several best-selling books, including 'The Plant Paradox' and 'The Gut-Brain Paradox'. With a focus on the impact of diet on health, Dr. Gundry has developed a unique approach to understanding how the gut microbiome influences overall well-being, including mental health and behavior. He is the founder of Gundry MD, a health and wellness company that offers supplements and resources aimed at improving gut health and overall vitality.

Topics Discussed

REHIT cardio fitness VO max exercise high-intensity training diabetes risk BDNF personalized exercise perimenopausal women bloodwork chronic fatigue cellular detox hormone resistance neurotoxicity energy metabolism wellness stress performance leadership productivity psychology resilience procrastination decision making Web3 genetics AI blockchain data ownership privacy cybernetic operating system biohacking decentralization data sovereignty gut microbiome brain chemistry addiction depression obesity inflammation Gut-Brain Paradox microbial command center probiotics neuroinflammation

YouTube Channel

Channel Info

Dave Asprey
@DaveAspreyBPR

Channel Stats

Subscribers: 104,000
Total Videos: 1,750
Total Views: 8,639,362
Joined: Nov 26, 2019
Location: United States

Description

Upgrading you, one cell at a time.

Over the last two decades Dave, “The Father of Biohacking”, has worked with world-renowned doctors, researchers, scientists, and global mavericks to uncover the latest, most innovative methods, techniques and products for enhancing mental and physical performance. Dave has personally spent over $2 million taking control of his own biology – pushing the bounds of human possibility all in the name of science evolution and revolution.

The creator of the Bulletproof Diet, and innovator of Bulletproof Coffee, Collagen Protein supplements and many more advances in commercial wellness products, Dave’s mission is to empower the entire globe with information and knowledge that unlocks the Super Human in everyone at any age. The proof of these advancements are better sleep, energy, and expanded capacity for all. Be a better partner, parent, provider and overall human being in every aspect of life.

Instagram Profile

Instagram

Profile Info

@dave.asprey
Dave Asprey

Account Stats

Followers: 1,271,473
Posts: 5,647

Account Status

Account Type: Business
Privacy: Public

Biography

⚡️ Created biohacking, Bulletproof founder
📙 4x NYT #longevity author
🎙 @thehumanupgradepodcast
🗣️ @the.biohackingconference
☕️ @dangercoffeeofficial

Episodes

Here's the recent few episodes on The Human Upgrade with Dave Asprey.

0:00 1:06:22

The End of Cardio? Burn Fat & Boost VO Max in Just 8 Minutes a Week with REHIT | Ulrich Dempfle : 1275

Hosts
Dave Asprey
Guests
Ulrich Dempfle
Keywords
REHIT cardio fitness VO max exercise high-intensity training diabetes risk BDNF personalized exercise perimenopausal women

Youve probably heard of HIITbut have you heard of REHIT?  This isnt just another workout trend...its a new science-backed way to train with maximum efficiency and zero wasted time. If youre still jogging, youre wasting hours for minimal results. 

In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained engineer and co-founder of CAROL Bike, to dismantle outdated cardio advice and introduce the 5-minute protocol thats obliterating fitness myths. 


Forget the treadmill grind. REHIT (Reduced Exertion High-Intensity Training) exercising delivers: 

12% VO max increase

6x the fitness gains of daily jogging 

62% drop in diabetes risk 

5x more BDNF for brain power 

all with just 8 minutes of effort per week. 


But was it? Ulrich unpacks the hard data, crushes the Zone 2 obsession, and shows how a brand-new way of exercising is giving explosive resultsno matter your age or fitness level. 


What Youll Learn in This Episode: 

Why Zone 2 cardio is outdated advice for most people 

The science of REHIT and how 2 sprints beat 2-hour workouts 

The shocking data on VO max, insulin sensitivity, and lifespan 

How CAROL uses AI to personalize exercise for any age or ability 

Why most people fail at fitnessand how to fix it 

The real role of lactate, BDNF, and HRV in recovery and resilience 

How perimenopausal women benefit more from REHIT than HIIT or jogging 

Why adherencenot intensityis the #1 predictor of results 

What to do when youre traveling or dont have access to the tech 


Resources:  

Dave Aspreys New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

CAROL Bike Website and use code DAVE for a discount   https://carolbike.com/ 

CAROL Bike Instagram - https://www.instagram.com/thecarolbike/?hl=en 

2025 Biohacking Conference: https://biohackingconference.com/2025 

Danger Coffee: https://dangercoffee.com 

Dave Aspreys Website: https://daveasprey.com 

Dave Aspreys Linktree: https://linktr.ee/daveasprey 

Upgrade Collective Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

Own an Upgrade Labs: https://ownanupgradelabs.com 

Upgrade Labs: https://upgradelabs.com 

40 Years of Zen Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 


Timestamps: 

00:00 Introduction to REHIT Training 

00:24 Meet Ulrich Dempfle: The Mind Behind CAROL Bike 

00:51 The Science and Benefits of REHIT 

01:44 Comparing Traditional Cardio to REHIT 

02:32 Dave Aspreys Personal Fitness Journey 

03:43 The Efficiency of REHIT Training 

05:03 Practical Applications and Accessibility of REHIT 

08:22 Addressing Common Concerns and Misconceptions 

11:25 The Future of Fitness: REHIT and Beyond 

18:29 Scientific Validation and Real-World Results 

31:53 Clinical Trials and Tech Integration 

32:06 Upgrade Labs and CAROL Bike 

33:00 Mitochondrial Effectiveness and Insulin Sensitivity 

36:05 Zone Two Training vs. High-Intensity Training 

42:02 REHIT for Perimenopausal Women 

48:18 AI and Personalized Exercise 

57:52 Lactate and Exercise Benefits 

01:01:48 Interval Walking Training 

01:04:01 Conclusion and Future Insights 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

0:00 1:18:47

The Real Reason You Still Feel TiredEven When Your Bloodwork Looks Perfect | Dr Pompa : 1273

Hosts
Dave Asprey
Guests
Dr. Daniel Pompa
Keywords
bloodwork chronic fatigue cellular detox hormone resistance neurotoxicity energy metabolism wellness

Your bloodwork looks normal. Your doctor says youre fine. But you still feel exhausted, inflamed, anxiousor worse. 

In this episode, Dave Asprey talks with Dr. Daniel Pompa, a leading voice in cellular detox and root-cause healing, to expose the hidden stressors hijacking your energy, hormones, and metabolismeven when your labs say youre healthy. 

Dr. Pompa shares his personal health collapse and reveals how cellular dysfunction, neurotoxicity, and hormone resistance drive the chronic fatigue epidemic. If youve ever felt dismissed by perfect bloodwork, this conversation will rewire how you think about sicknessand show you how to reclaim real, lasting wellness. 


What Youll Learn in This Episode: 

Why your bloodwork can be perfect while your cells are on fire 

The overlooked hormone resistances sabotaging your energy and metabolism 

The 3-legged stool of chronic illnessand what actually drives disease 

What upstream detox really means, and why most cleanses make you worse 

Why toxins trigger genetic expression (and how to shut that down) 

How to fix unexplainable fatigue, anxiety, and weight gain from the inside out 

Why true healing starts with fixing the cell, not the symptom 


Its time to stop chasing symptomsand start upgrading from the root. 


**Check out Dr. Pompas EXCLUSIVE protocol built for The Human Upgrade listeners at davetestkit.com and use code 10OFF for a discount!** 

 

SPONSORS 

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.  

-Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. 


 

Resources:  

Dave Aspreys New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

Dr. Pompas Website   https://drpompa.com/ 

Dr. Pompas Instagram - https://www.instagram.com/drpompa/?hl=en 

2025 Biohacking Conference: https://biohackingconference.com/2025 

Danger Coffee: https://dangercoffee.com 

Dave Aspreys Website: https://daveasprey.com 

Dave Aspreys Linktree: https://linktr.ee/daveasprey 

Upgrade Collective Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

Own an Upgrade Labs: https://ownanupgradelabs.com 

Upgrade Labs: https://upgradelabs.com 

40 Years of Zen Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 


Timestamps: 

 00:00 Trailer 

 00:55 Intro 

 01:10 Healthy Is the New Sick 

 02:27 Bloodwork & Hormone Resistance 

 04:32 Dr. Pompas Health Collapse 

 08:38 Toxins & Environmental Triggers 

 15:01 Why Most Detox Fails 

 29:16 The 5 Rs of Cellular Healing 

 37:06 Olive Oil: Cure or Concern? 

 38:11 Fat Balance for Energy 

 42:13 Cholesterol & Saturated Fat 

 46:26 Restoring Cellular Energy 

 51:08 The Power of Diet Variation 

 56:57 Plant Toxins Explained 

 01:03:28 Emotional & Spiritual Detox 

 01:13:55 Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

0:00 1:20:27

The $500 Billion Secret: Why Top Leaders Chase Stress | Sbastien Page : 1272

Hosts
Dave Asprey
Guests
Sbastien Page
Keywords
stress performance leadership productivity psychology resilience procrastination decision making

Most people run from stress. The worlds highest performers run toward it. 

Sbastien Page manages over $500 billion in global assets. Hes the CIO of one of the worlds largest investment firms, and he wrote The Psychology of Leadership while living under relentless pressure. His secret? He doesnt avoid stresshe uses it as a tool for performance, clarity, and control. 

But heres the twist: this isnt just about boardrooms or billion-dollar trades. 

Whether youre running a company, chasing a deadline, or just trying to stop procrastinating on your goalsthis conversation will flip what you think you know about pressure, performance, and productivity

Youll learn why trying to relax your way to success doesnt workand how to harness discomfort to create better decisions, higher output, and more resilience in every part of life. 


What Youll Learn in This Episode: 

The psychology of stress and why zero stress leads to burnout 

How procrastination can boost creative performance 

What astronauts, athletes, and leaders have in common 

Why the key to better decisions is strategic patience, not speed 

The stress-performance curve no one taught you in school 

Why losing is the real path to mastery (and what Roger Federer can teach you) 

The difference between being nice vs. being kindand why it matters 


It's time to start turning stress into strategy


SPONSORS 

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.  

-BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. 


 Resources:  

Dave Aspreys New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

Sbastiens New Book The Psychology of Leadership   https://www.psychologyofleadership.net/ 

2025 Biohacking Conference: https://biohackingconference.com/2025 

Danger Coffee: https://dangercoffee.com 

Dave Aspreys Website: https://daveasprey.com 

Dave Aspreys Linktree: https://linktr.ee/daveasprey 

Upgrade Collective Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

Own an Upgrade Labs: https://ownanupgradelabs.com 

Upgrade Labs: https://upgradelabs.com 

40 Years of Zen Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 


 

Timestamps: 

 00:00 Intro 

 02:00 Book Launch & Setup 

 02:45 Buy or Sell? Market Insights 

 03:20 Stress and Performance 

 04:28 Sports Psychology Breakdown 

 09:48 Federer & the Power of Losing 

 26:42 Rethinking Feedback 

 31:32 Stress as a Tool 

 44:10 Listening as Leadership 

 44:17 Traits of Great Leaders 

 44:54 Psychology for Entrepreneurs 

 45:37 Leading Beyond Work 

 46:09 Sleep Tracking Anxiety 

 47:39 Channeling Stress 

 49:04 Extreme Pressure Moments 

 50:42 The Corporate Athlete 

 59:08 Vulnerability & Leadership 

 01:05:23 Goal-Induced Blindness 

 01:12:34 Finding Meaning at Work 

 01:18:08 Leadership at Home 

 01:20:27 Final Takeaways 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

0:00 1:30:03

Web3 & the Future of Genetics: AI, Blockchain & Data Ownership with Nillion : 1271

Hosts
Dave Asprey
Guests
Michael Tiffany Vishakh
Keywords
Web3 genetics AI blockchain data ownership privacy cybernetic operating system biohacking decentralization data sovereignty

Your DNA, health data, and digital identity are encrypted, monetized, and weaponized against you. 

But what if there was a way to take it back… and hack the system? 

In this mind-expanding episode, Dave sits down with two elite hacker-founders—Michael Tiffany, CEO of Fulcra.ai, and Vishakh, founder of Monadic DNA—to explore a radical shift in the way we store, protect, and use our most personal data. 

Together, they break down the Web3 tech stack powering this revolution. Enter Nillion, a distributed, privacy-preserving compute network that allows you to share and analyze your encrypted data… without ever giving it away. 

From genomic privacy to AI sovereignty, this episode exposes the hidden architecture of control—and how to escape it. You’ll learn how cutting-edge blockchain and cryptography are rewriting the rules of ownership, consent, and even identity itself. 


What You’ll Learn in This Episode: 

• Why your DNA is already in government databases—and how long they keep it 

• How Nillion enables secure computation on private data 

• What it means to build a “cybernetic operating system” for your body 

• Why Fulcra.ai is building the orchestration layer of human optimization 

• How Monadic DNA helps you profit from your genetics—without giving them away 

• Why owning your data is the next frontier of biohacking 

• The surprising connection between decentralization, health freedom, and consciousness 

• How to join the movement toward true data sovereignty 


If you’ve ever felt like you’re giving away too much to big tech, big pharma, or just the internet itself—this conversation will change how you see your data… and your body. 


**Join the Fulca sleep study today! Visit https://fulcra.ai/sleep to sign up** 

**Get a 30% discount on Fulca with code “DAVE”!  


SPONSORS 

-IGNITON | Go to https://www.biohackingconference.com/ and get your tickets while there are still great discounts available. Learn more at https://igniton.com/.  

-Calroy | Head to https://calroy.com/dave for an exclusive discount. 


Resources:  

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

Fulcra Dynamics Website –  https://www.fulcradynamics.com/ 

MonadicDNA Website: https://monadicdna.com/ 

2025 Biohacking Conference: https://biohackingconference.com/2025 

Danger Coffee: https://dangercoffee.com 

Dave Asprey’s Website: https://daveasprey.com 

Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

Own an Upgrade Labs: https://ownanupgradelabs.com 

Upgrade Labs: https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

 

Timestamps: 

• 00:00 – Trailer 

• 02:01 – Intro 

• 02:26 – Data Privacy & AI: The Big Shift 

• 03:21 – Meet Michael Tiffany 

• 04:41 – Cybernetic Operating Systems 

• 05:13 – Wearables & Personal Augmentation 

• 08:21 – Meet Vishakh: DNA Privacy Mission 

• 09:25 – Why Genetic Data Needs Protection 

• 11:30 – New Tech: Encryption & Privacy Tools 

• 16:13 – How Multi-Party Compute Works 

• 41:58 – Emergence: Behavior & Systems 

• 49:11 – Meditation & Mental Reprogramming 

• 50:20 – Distributed Computing & Biology 

• 56:15 – Environment Shapes Potential 

• 57:57 – Empowering Individuals at Scale 

• 01:00:31 – Biohacking Meets Inner Awareness 

• 01:04:01 – The Dark Side of DIY Mind Hacks 

• 01:06:09 – Future of Biohacking & Community

• 01:12:28 – Integrating Genetic & Life Data 

• 01:20:39 – Why We Started Biohacking 

• 01:25:01 – Favorite Current Biohacks 

• 01:31:41 – Final Thoughts & Resources 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

0:00 54:11

Dr. Steven Gundry: Is Fungus Secretly Running the World—and Your Gut? : 1270

Hosts
Dave Asprey
Guests
Dr. Steven Gundry
Keywords
gut microbiome brain chemistry addiction depression obesity inflammation Gut-Brain Paradox microbial command center probiotics neuroinflammation

If your brain feels foggy, your mood swings like a pendulum, or your cravings seem to control you—this episode will flip what you think you know about your body and your mind. Because what if your thoughts… aren’t really yours? 

In this mind-altering episode of The Human Upgrade, Dr. Steven Gundry reveals a startling new theory: your gut microbiome might be controlling your thoughts. From addiction and depression to obesity and inflammation, the microbes living in your gut—bacteria, fungi, viruses, even parasites—may be pulling the strings on your brain chemistry, mood, and behavior. 

Dave Asprey and Dr. Gundry dive deep into The Gut-Brain Paradox, exposing how the gut-brain axis operates more like a microbial command center than a digestive system. You’ll learn why probiotic pills rarely work, how the wrong microbes can drive compulsive behavior, and how toxic foods, glyphosate, and antibiotics have turned our guts into neurological war zones. 

Most shocking of all? Microbes may not just influence addiction—they may cause it. 


What You’ll Learn in This Episode: 

• How your gut microbiome can hijack your brain and influence your thoughts and behavior 

• Why certain microbes may actually cause addiction, obesity, and depression 

• How antibiotics, glyphosate, and processed foods are turning your gut into a desert 

• How to rebuild your gut ecosystem using postbiotics, fermented foods, and precision inputs 

• Why food cravings might be microbial mind control—and what to do about it 

• What the latest science reveals about the gut-brain axis, neurotransmitters, and neuroinflammation 


Sponsors: 

-Sunlighten | Go to https://www.sunlighten.com/dave/ and enter code DAVE at checkout to save up to $1,400.  

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 


Resources:  

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

Dr. Gundry’s Instagram –  https://www.instagram.com/drstevengundry/?hl=en 

Dr. Gundry’s Website: https://drgundry.com/ 

Dr. Gundry’s New Book The Gut-Brain Paradox: https://www.barnesandnoble.com/w/the-gut-brain-paradox-steven-r-gundry-md/1146019686?ean=9780062911803 

2025 Biohacking Conference: https://biohackingconference.com/2025 

Danger Coffee: https://dangercoffee.com 

Dave Asprey’s Website: https://daveasprey.com 

Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

Own an Upgrade Labs: https://ownanupgradelabs.com 

Upgrade Labs: https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 


Timestamps: 

• 00:00 — Trailer 

• 02:01 — Intro 

• 03:55 — The Gut-Brain Connection 

• 04:45 — Microbiome Communication and Control 

• 08:19 — The Role of Fungi and Plants 

• 11:29 — Microbiome Diversity and Health 

• 19:05 — Addictive Microbiome and Behavior 

• 28:17 — Antibiotics and Gut Health 

• 30:49 — Listener Concerns and Gut Health 

• 31:02 — Whale Watching and Climate Change 

• 32:58 — Understanding SIBO and Bacterial Migration 

• 34:02 — The Role of Soluble Fiber and Fermented Foods 

• 36:12 — Complexity of Gut Microbiome 

• 36:49 — Restoring Ecosystems and Gut Health 

• 38:23 — Precision Microbiome Manipulation 

• 41:31 — Calcium Formation and Gut Bacteria 

• 43:56 — Oxalates vs. Lectins Debate 

• 46:04 — Whole Foods and Glyphosate Concerns 

• 51:47 — Dopamine Levels and Gut Health 

• 54:59 — Conclusion and Book Promotion 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ratings

Global:
4.6 rating 9009 reviews

USA

4.6 ratings 6800 reviews

Canada

4.7 ratings 947 reviews

Australia

4.7 ratings 647 reviews

UK

4.6 ratings 457 reviews

New Zealand

4.6 ratings 61 reviews

South Africa

4.8 ratings 50 reviews

Ireland

4.6 ratings 34 reviews

Singapore

4.5 ratings 13 reviews