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For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.
You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.
Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.
Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.
You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.
Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.
Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
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Here's a quick summary of the last 5 episodes on The Human Upgrade with Dave Asprey.
Hosts
Dave Asprey
Previous Guests
Ulrich Dempfle
Ulrich Dempfle is a German-trained engineer and co-founder of CAROL Bike, a company that specializes in creating innovative fitness solutions. With a background in engineering, Ulrich has dedicated his career to developing efficient training methods that challenge traditional cardio workouts. He is a proponent of Reduced Exertion High-Intensity Training (REHIT), which emphasizes short, intense bursts of exercise to achieve significant fitness gains in minimal time. His work focuses on dismantling outdated fitness myths and providing data-driven insights into effective training protocols.
Ulrich Dempfle is a German-trained engineer and co-founder of CAROL Bike, a company that specializes in creating innovative fitness solutions. With a background in engineering, Ulrich has dedicated his career to developing efficient training methods that challenge traditional cardio workouts. He is a proponent of Reduced Exertion High-Intensity Training (REHIT), which emphasizes short, intense bursts of exercise to achieve significant fitness gains in minimal time. His work focuses on dismantling outdated fitness myths and providing data-driven insights into effective training protocols.
Dr. Daniel Pompa
Dr. Daniel Pompa is a leading voice in cellular detox and root-cause healing. He has a background in health and wellness, focusing on the underlying causes of chronic illness. Dr. Pompa has experienced a personal health collapse, which has driven his passion for understanding cellular dysfunction, neurotoxicity, and hormone resistance. He is known for his work in exposing hidden stressors that affect energy and overall health, and he advocates for a holistic approach to healing that addresses the root causes rather than just symptoms.
Dr. Daniel Pompa is a leading voice in cellular detox and root-cause healing. He has a background in health and wellness, focusing on the underlying causes of chronic illness. Dr. Pompa has experienced a personal health collapse, which has driven his passion for understanding cellular dysfunction, neurotoxicity, and hormone resistance. He is known for his work in exposing hidden stressors that affect energy and overall health, and he advocates for a holistic approach to healing that addresses the root causes rather than just symptoms.
Sbastien Page
Sbastien Page is the Chief Investment Officer (CIO) of one of the world's largest investment firms, managing over $500 billion in global assets. He is also the author of 'The Psychology of Leadership,' a book that explores the dynamics of leadership under pressure. With extensive experience in high-stakes environments, Page has developed a unique perspective on stress, viewing it not as a hindrance but as a tool for enhancing performance, clarity, and control. His insights draw from his experiences in the financial sector and his understanding of the psychological aspects of leadership.
Sbastien Page is the Chief Investment Officer (CIO) of one of the world's largest investment firms, managing over $500 billion in global assets. He is also the author of 'The Psychology of Leadership,' a book that explores the dynamics of leadership under pressure. With extensive experience in high-stakes environments, Page has developed a unique perspective on stress, viewing it not as a hindrance but as a tool for enhancing performance, clarity, and control. His insights draw from his experiences in the financial sector and his understanding of the psychological aspects of leadership.
Michael Tiffany
Michael Tiffany is the CEO of Fulcra.ai, a company focused on developing advanced technologies for data privacy and security. With a background in computer science and a passion for innovation, he has been at the forefront of integrating AI and blockchain to enhance personal data protection and ownership.
Michael Tiffany is the CEO of Fulcra.ai, a company focused on developing advanced technologies for data privacy and security. With a background in computer science and a passion for innovation, he has been at the forefront of integrating AI and blockchain to enhance personal data protection and ownership.
Vishakh
Vishakh is the founder of Monadic DNA, a company dedicated to revolutionizing the way genetic data is handled and monetized. He is an expert in genomic privacy and has a mission to empower individuals to profit from their genetic information while ensuring its security and confidentiality.
Vishakh is the founder of Monadic DNA, a company dedicated to revolutionizing the way genetic data is handled and monetized. He is an expert in genomic privacy and has a mission to empower individuals to profit from their genetic information while ensuring its security and confidentiality.
Dr. Steven Gundry
Dr. Steven Gundry is a renowned cardiothoracic surgeon and a pioneer in the field of nutrition and gut health. He is the author of several best-selling books, including 'The Plant Paradox' and 'The Gut-Brain Paradox'. With a focus on the impact of diet on health, Dr. Gundry has developed a unique approach to understanding how the gut microbiome influences overall well-being, including mental health and behavior. He is the founder of Gundry MD, a health and wellness company that offers supplements and resources aimed at improving gut health and overall vitality.
Dr. Steven Gundry is a renowned cardiothoracic surgeon and a pioneer in the field of nutrition and gut health. He is the author of several best-selling books, including 'The Plant Paradox' and 'The Gut-Brain Paradox'. With a focus on the impact of diet on health, Dr. Gundry has developed a unique approach to understanding how the gut microbiome influences overall well-being, including mental health and behavior. He is the founder of Gundry MD, a health and wellness company that offers supplements and resources aimed at improving gut health and overall vitality.
Topics Discussed
REHIT
cardio
fitness
VO max
exercise
high-intensity training
diabetes risk
BDNF
personalized exercise
perimenopausal women
bloodwork
chronic fatigue
cellular detox
hormone resistance
neurotoxicity
energy
metabolism
wellness
stress
performance
leadership
productivity
psychology
resilience
procrastination
decision making
Web3
genetics
AI
blockchain
data ownership
privacy
cybernetic operating system
biohacking
decentralization
data sovereignty
gut microbiome
brain chemistry
addiction
depression
obesity
inflammation
Gut-Brain Paradox
microbial command center
probiotics
neuroinflammation
Over the last two decades Dave, “The Father of Biohacking”, has worked with world-renowned doctors, researchers, scientists, and global mavericks to uncover the latest, most innovative methods, techniques and products for enhancing mental and physical performance. Dave has personally spent over $2 million taking control of his own biology – pushing the bounds of human possibility all in the name of science evolution and revolution.
The creator of the Bulletproof Diet, and innovator of Bulletproof Coffee, Collagen Protein supplements and many more advances in commercial wellness products, Dave’s mission is to empower the entire globe with information and knowledge that unlocks the Super Human in everyone at any age. The proof of these advancements are better sleep, energy, and expanded capacity for all. Be a better partner, parent, provider and overall human being in every aspect of life.
Here's the recent few episodes on The Human Upgrade with Dave Asprey.
0:001:06:22
The End of Cardio? Burn Fat & Boost VO Max in Just 8 Minutes a Week with REHIT | Ulrich Dempfle : 1275
Hosts
Hosts of this podcast episode
Dave Asprey
Guests
Guests of this podcast episode
Ulrich Dempfle
Keywords
Keywords of this podcast episode
REHITcardiofitnessVO maxexercisehigh-intensity trainingdiabetes riskBDNFpersonalized exerciseperimenopausal women
Youve probably heard of HIITbut have you heard of REHIT? This isnt just another workout trend...its a new science-backed way to train with maximum efficiency and zero wasted time. If youre still jogging, youre wasting hours for minimal results.
In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained engineer and co-founder of CAROL Bike, to dismantle outdated cardio advice and introduce the 5-minute protocol thats obliterating fitness myths.
But was it? Ulrich unpacks the hard data, crushes the Zone 2 obsession, and shows how a brand-new way of exercising is giving explosive resultsno matter your age or fitness level.
What Youll Learn in This Episode:
Why Zone 2 cardio is outdated advice for most people
The science of REHIT and how 2 sprints beat 2-hour workouts
The shocking data on VO max, insulin sensitivity, and lifespan
How CAROL uses AI to personalize exercise for any age or ability
Why most people fail at fitnessand how to fix it
The real role of lactate, BDNF, and HRV in recovery and resilience
How perimenopausal women benefit more from REHIT than HIIT or jogging
Why adherencenot intensityis the #1 predictor of results
What to do when youre traveling or dont have access to the tech
Youve probably heard of HIITbut have you heard of REHIT? This isnt just another workout trend...its a new science-backed way to train with maximum efficiency and zero wasted time. If youre still jogging, youre wasting hours for minimal results.
In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained engineer and co-founder of CAROL Bike, to dismantle outdated cardio advice and introduce the 5-minute protocol thats obliterating fitness myths.
But was it? Ulrich unpacks the hard data, crushes the Zone 2 obsession, and shows how a brand-new way of exercising is giving explosive resultsno matter your age or fitness level.
What Youll Learn in This Episode:
Why Zone 2 cardio is outdated advice for most people
The science of REHIT and how 2 sprints beat 2-hour workouts
The shocking data on VO max, insulin sensitivity, and lifespan
How CAROL uses AI to personalize exercise for any age or ability
Why most people fail at fitnessand how to fix it
The real role of lactate, BDNF, and HRV in recovery and resilience
How perimenopausal women benefit more from REHIT than HIIT or jogging
Why adherencenot intensityis the #1 predictor of results
What to do when youre traveling or dont have access to the tech
Your bloodwork looks normal. Your doctor says youre fine. But you still feel exhausted, inflamed, anxiousor worse.
In this episode, Dave Asprey talks with Dr. Daniel Pompa, a leading voice in cellular detox and root-cause healing, to expose the hidden stressors hijacking your energy, hormones, and metabolismeven when your labs say youre healthy.
Dr. Pompa shares his personal health collapse and reveals how cellular dysfunction, neurotoxicity, and hormone resistance drive the chronic fatigue epidemic. If youve ever felt dismissed by perfect bloodwork, this conversation will rewire how you think about sicknessand show you how to reclaim real, lasting wellness.
What Youll Learn in This Episode:
Why your bloodwork can be perfect while your cells are on fire
The overlooked hormone resistances sabotaging your energy and metabolism
The 3-legged stool of chronic illnessand what actually drives disease
What upstream detox really means, and why most cleanses make you worse
Why toxins trigger genetic expression (and how to shut that down)
How to fix unexplainable fatigue, anxiety, and weight gain from the inside out
Why true healing starts with fixing the cell, not the symptom
Its time to stop chasing symptomsand start upgrading from the root.
**Check out Dr. Pompas EXCLUSIVE protocol built for The Human Upgrade listeners at davetestkit.com and use code 10OFF for a discount!**
Your bloodwork looks normal. Your doctor says youre fine. But you still feel exhausted, inflamed, anxiousor worse.
In this episode, Dave Asprey talks with Dr. Daniel Pompa, a leading voice in cellular detox and root-cause healing, to expose the hidden stressors hijacking your energy, hormones, and metabolismeven when your labs say youre healthy.
Dr. Pompa shares his personal health collapse and reveals how cellular dysfunction, neurotoxicity, and hormone resistance drive the chronic fatigue epidemic. If youve ever felt dismissed by perfect bloodwork, this conversation will rewire how you think about sicknessand show you how to reclaim real, lasting wellness.
What Youll Learn in This Episode:
Why your bloodwork can be perfect while your cells are on fire
The overlooked hormone resistances sabotaging your energy and metabolism
The 3-legged stool of chronic illnessand what actually drives disease
What upstream detox really means, and why most cleanses make you worse
Why toxins trigger genetic expression (and how to shut that down)
How to fix unexplainable fatigue, anxiety, and weight gain from the inside out
Why true healing starts with fixing the cell, not the symptom
Its time to stop chasing symptomsand start upgrading from the root.
**Check out Dr. Pompas EXCLUSIVE protocol built for The Human Upgrade listeners at davetestkit.com and use code 10OFF for a discount!**
The $500 Billion Secret: Why Top Leaders Chase Stress | Sbastien Page : 1272
Hosts
Hosts of this podcast episode
Dave Asprey
Guests
Guests of this podcast episode
Sbastien Page
Keywords
Keywords of this podcast episode
stressperformanceleadershipproductivitypsychologyresilienceprocrastinationdecision making
Most people run from stress. The worlds highest performers run toward it.
Sbastien Page manages over $500 billion in global assets. Hes the CIO of one of the worlds largest investment firms, and he wrote The Psychology of Leadership while living under relentless pressure. His secret? He doesnt avoid stresshe uses it as a tool for performance, clarity, and control.
But heres the twist: this isnt just about boardrooms or billion-dollar trades.
Whether youre running a company, chasing a deadline, or just trying to stop procrastinating on your goalsthis conversation will flip what you think you know about pressure, performance, and productivity.
Youll learn why trying to relax your way to success doesnt workand how to harness discomfort to create better decisions, higher output, and more resilience in every part of life.
What Youll Learn in This Episode:
The psychology of stress and why zero stress leads to burnout
How procrastination can boost creative performance
What astronauts, athletes, and leaders have in common
Why the key to better decisions is strategic patience, not speed
The stress-performance curve no one taught you in school
Why losing is the real path to mastery (and what Roger Federer can teach you)
The difference between being nice vs. being kindand why it matters
It's time to start turning stress into strategy.
SPONSORS
-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.
-BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino.
Most people run from stress. The worlds highest performers run toward it.
Sbastien Page manages over $500 billion in global assets. Hes the CIO of one of the worlds largest investment firms, and he wrote The Psychology of Leadership while living under relentless pressure. His secret? He doesnt avoid stresshe uses it as a tool for performance, clarity, and control.
But heres the twist: this isnt just about boardrooms or billion-dollar trades.
Whether youre running a company, chasing a deadline, or just trying to stop procrastinating on your goalsthis conversation will flip what you think you know about pressure, performance, and productivity.
Youll learn why trying to relax your way to success doesnt workand how to harness discomfort to create better decisions, higher output, and more resilience in every part of life.
What Youll Learn in This Episode:
The psychology of stress and why zero stress leads to burnout
How procrastination can boost creative performance
What astronauts, athletes, and leaders have in common
Why the key to better decisions is strategic patience, not speed
The stress-performance curve no one taught you in school
Why losing is the real path to mastery (and what Roger Federer can teach you)
The difference between being nice vs. being kindand why it matters
It's time to start turning stress into strategy.
SPONSORS
-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.
-BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino.
Your DNA, health data, and digital identity are encrypted, monetized, and weaponized against you.
But what if there was a way to take it back… and hack the system?
In this mind-expanding episode, Dave sits down with two elite hacker-founders—Michael Tiffany, CEO of Fulcra.ai, and Vishakh, founder of Monadic DNA—to explore a radical shift in the way we store, protect, and use our most personal data.
Together, they break down the Web3 tech stack powering this revolution. Enter Nillion, a distributed, privacy-preserving compute network that allows you to share and analyze your encrypted data… without ever giving it away.
From genomic privacy to AI sovereignty, this episode exposes the hidden architecture of control—and how to escape it. You’ll learn how cutting-edge blockchain and cryptography are rewriting the rules of ownership, consent, and even identity itself.
What You’ll Learn in This Episode:
• Why your DNA is already in government databases—and how long they keep it
• How Nillion enables secure computation on private data
• What it means to build a “cybernetic operating system” for your body
• Why Fulcra.ai is building the orchestration layer of human optimization
• How Monadic DNA helps you profit from your genetics—without giving them away
• Why owning your data is the next frontier of biohacking
• The surprising connection between decentralization, health freedom, and consciousness
• How to join the movement toward true data sovereignty
If you’ve ever felt like you’re giving away too much to big tech, big pharma, or just the internet itself—this conversation will change how you see your data… and your body.
Your DNA, health data, and digital identity are encrypted, monetized, and weaponized against you.
But what if there was a way to take it back… and hack the system?
In this mind-expanding episode, Dave sits down with two elite hacker-founders—Michael Tiffany, CEO of Fulcra.ai, and Vishakh, founder of Monadic DNA—to explore a radical shift in the way we store, protect, and use our most personal data.
Together, they break down the Web3 tech stack powering this revolution. Enter Nillion, a distributed, privacy-preserving compute network that allows you to share and analyze your encrypted data… without ever giving it away.
From genomic privacy to AI sovereignty, this episode exposes the hidden architecture of control—and how to escape it. You’ll learn how cutting-edge blockchain and cryptography are rewriting the rules of ownership, consent, and even identity itself.
What You’ll Learn in This Episode:
• Why your DNA is already in government databases—and how long they keep it
• How Nillion enables secure computation on private data
• What it means to build a “cybernetic operating system” for your body
• Why Fulcra.ai is building the orchestration layer of human optimization
• How Monadic DNA helps you profit from your genetics—without giving them away
• Why owning your data is the next frontier of biohacking
• The surprising connection between decentralization, health freedom, and consciousness
• How to join the movement toward true data sovereignty
If you’ve ever felt like you’re giving away too much to big tech, big pharma, or just the internet itself—this conversation will change how you see your data… and your body.
Dr. Steven Gundry: Is Fungus Secretly Running the World—and Your Gut? : 1270
Hosts
Hosts of this podcast episode
Dave Asprey
Guests
Guests of this podcast episode
Dr. Steven Gundry
Keywords
Keywords of this podcast episode
gut microbiomebrain chemistryaddictiondepressionobesityinflammationGut-Brain Paradoxmicrobial command centerprobioticsneuroinflammation
If your brain feels foggy, your mood swings like a pendulum, or your cravings seem to control you—this episode will flip what you think you know about your body and your mind. Because what if your thoughts… aren’t really yours?
In this mind-altering episode of The Human Upgrade, Dr. Steven Gundry reveals a startling new theory: your gut microbiome might be controlling your thoughts. From addiction and depression to obesity and inflammation, the microbes living in your gut—bacteria, fungi, viruses, even parasites—may be pulling the strings on your brain chemistry, mood, and behavior.
Dave Asprey and Dr. Gundry dive deep into The Gut-Brain Paradox, exposing how the gut-brain axis operates more like a microbial command center than a digestive system. You’ll learn why probiotic pills rarely work, how the wrong microbes can drive compulsive behavior, and how toxic foods, glyphosate, and antibiotics have turned our guts into neurological war zones.
Most shocking of all? Microbes may not just influence addiction—they may cause it.
What You’ll Learn in This Episode:
• How your gut microbiome can hijack your brain and influence your thoughts and behavior
• Why certain microbes may actually cause addiction, obesity, and depression
• How antibiotics, glyphosate, and processed foods are turning your gut into a desert
• How to rebuild your gut ecosystem using postbiotics, fermented foods, and precision inputs
• Why food cravings might be microbial mind control—and what to do about it
• What the latest science reveals about the gut-brain axis, neurotransmitters, and neuroinflammation
If your brain feels foggy, your mood swings like a pendulum, or your cravings seem to control you—this episode will flip what you think you know about your body and your mind. Because what if your thoughts… aren’t really yours?
In this mind-altering episode of The Human Upgrade, Dr. Steven Gundry reveals a startling new theory: your gut microbiome might be controlling your thoughts. From addiction and depression to obesity and inflammation, the microbes living in your gut—bacteria, fungi, viruses, even parasites—may be pulling the strings on your brain chemistry, mood, and behavior.
Dave Asprey and Dr. Gundry dive deep into The Gut-Brain Paradox, exposing how the gut-brain axis operates more like a microbial command center than a digestive system. You’ll learn why probiotic pills rarely work, how the wrong microbes can drive compulsive behavior, and how toxic foods, glyphosate, and antibiotics have turned our guts into neurological war zones.
Most shocking of all? Microbes may not just influence addiction—they may cause it.
What You’ll Learn in This Episode:
• How your gut microbiome can hijack your brain and influence your thoughts and behavior
• Why certain microbes may actually cause addiction, obesity, and depression
• How antibiotics, glyphosate, and processed foods are turning your gut into a desert
• How to rebuild your gut ecosystem using postbiotics, fermented foods, and precision inputs
• Why food cravings might be microbial mind control—and what to do about it
• What the latest science reveals about the gut-brain axis, neurotransmitters, and neuroinflammation